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Initiating antiretroviral therapy (ART) as early as the day of HIV diagnosis is a strategy of increasing global interest to control the HIV epidemic and optimize the health of people living with HIV (PLWH). No detrimental effects of rapid‐start ART have been identified in randomized controlled trials undertaken in low‐ or middle‐income countries, or in cohort studies performed in high‐income countries...
Three‐drug combination antiretroviral therapy (ART) became available in 1996, dramatically improving the prognosis of people living with HIV. The clinical benefits of ART are due to the sustained viral load suppression and CD4 T cell gains. Major drawbacks of the first ART regimens were adverse events, and high pill burden, which led to the reduction of drug adherence resulting in frequent treatment...
Since the introduction of suppressive antiretroviral therapy (ART), HIV has become a chronic disease, with infected people in high‐income countries approaching similar life expectancy to the general population. As this population ages, an increasing number of people with HIV are living with age‐, treatment‐, and disease‐related comorbidities. Lifestyle factors such as smoking, alcohol abuse, and substance...
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